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KMID : 0360320010330020093
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Journal of Korean Cancer Research Association
2001 Volume.33 No. 2 p.93 ~ p.98
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The Role of Expression of Vascular Endothelial Growth Factor (VEGF)-A and VEGF-C in Early Gastric Cancer
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Yook Jeong-Hwan
Ugoe Shoji-Nats
Ugoe Shoji-Nats
Che Xiangming
Sumiya Is higami
Kita Shuichi Ho
Baba Masamichi
Takao Sonshin
Aikou Takas-hi
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Abstract
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Purpose :Tumor spread is mainly dependent on both hematogenous and lymphogeneous systems, and recently, several angiogenic factors have been identified. In the present study, we investigated whether the expressions of VEGF-A and -C are related with angiogenesis and lymph node metastasis in early gastric cancer.
Materials and Methods :A total of 97 specimens obtained from patients with early gastric cancer were studied by immunohistochemical methods using anti- VEGF-A and -C polyclonal antibodies, anti-Factor VIII- related antigen antibody, and anti-p53 antibody.
Results :The percentage of the positive expressions of VEGF-A and -C were 24.7% (24/97) and 25.7% (25/97), respectively. Significant differences were found between the expression of VEGF-A and lymphatic invasion and lymph node metastasis, and between expression of VEGF-C and gross type, lymphatic invasion, and lymph node metastasis (p＜0.05). The mean microvessel counts in VEGF-A and -C positive tumors were significantly higher than those in VEGF-A and -C negative tumors (p＜0.05). In multivariate analysis, tumor size, lymphatic invasion and VEGF-C were identified as independent factors related to lymph node metastasis (p＜0.05).
Conclusion :The expressions of VEGF-A and -C were found to be related to angiogenic activity and VEGF-C expression correlated significantly with lymph node metastasis. The determination of VEGF-C expression may be helpful for predicting lymph node metastases in early gastric cancer, and further studies involving many specimens are warranted.
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KEYWORD
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Vascular endothelial growth factor, Angiogenesis, Lymph node metastasis, Early stomach neoplasm,
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